This combination can result in an individual consuming a much stronger substance than they are used to, resulting in overdose and possibly death. The DEA has found an average of 2.4 milligrams of fentanyl in the pills they test (DEA, 2024). People who use drugs might not be aware they are taking fentanyl, yet the reality is that fentanyl-laced drugs are prevalent.
Public Health
There are two types of fentanyl – pharmaceutical fentanyl and illegally made fentanyl. Fentanyl, synthetic narcotic analgesic drug, the most potent narcotic in clinical use (50 to 100 times more potent than morphine). The citrate salt, fentanyl citrate, is administered by injection, either intramuscularly or intravenously, sometimes in combination with a potent tranquilizer. If the patient has used a monoamine oxidase inhibitor in the previous 14 days, fentanyl is contraindicated. A harm-reduction organization in Vancouver is helping people addicted to opioids buy pharmaceutical-grade fentanyl at street prices as an alternative to the illicit drug supply—a first in North America.

Why Is Fentanyl In The Drug Supply?
A small dose of fentanyl can be fatal depending on how tolerant someone is and their body size. Coroners’ offices and state crime laboratories do not test for fentanyl unless given a specific reason to do so. In this article, we will discuss the medical uses of fentanyl and its side effects. We will also cover misuse of fentanyl, addiction, and the risk of overdose. This campaign also shows the difference between counterfeit pills and real pills.
Responding To An Overdose
These facilities offer a structured and closely monitored setting where individuals can commit fully to their recovery. Guided by medical professionals and an array of therapeutic modalities, inpatient programs equip you with the necessary tools to break free from the grip of addiction. The Drug Enforcement Administration (DEA) estimates that obtaining a kilogram (roughly 2.2 pounds) of powdered fentanyl from China could cost a few thousand dollars. But once this powder is converted into hundreds of thousands of pills, the street value could soar into the millions of dollars. The information on this site is for educational purposes only, and does not substitute for professional medical advice.
Breathing Difficulties

Opioids are a class of drugs that include both prescription medicines such as morphine and illegal drugs like heroin. They have been working on this investigation since last year, and their full findings will be reviewed at a Senate hearing on Thursday. For example, a Fentanyl-laced Percocet M-30 pill can cost the buyer between $20 to $30 a pill. The seller will also feature Xanax, “MUHA MINIS”, which is lingo used for vape cartridges, starting at $40 a cartridge.
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The program not only educates parents and students but also school officials including administrators and teachers. FOX26 News confirmed with Fresno Unified School District beginning this year all middle and high schools will carry Narcan. The reversing agent is administered through a nasal spray reversing the effect of an opioid overdose, in particular, fentanyl. Despite the number of overdoses Det. Cardinale has seen in the Valley, he believes the F.O.R.T. program is working.
- Lastly, fentanyl use can extend to the treatment of epilepsy.
- Fentanyl is estimated to be about 100 times more potent than morphine and 50 times more potent than heroin as a pain reliever.
- There are more than 30 nonpharmaceutical-grade fentanyl analogs circulating on the illicit drug market, many of which cannot be detected on standard urine drug screens.
- When confronting opioid addiction, the road to recovery offers several distinct routes, each catering to diverse needs and circumstances.
Abuse And Fentanyl
In 2022, the DEA seized more than 50 million street pills laced with fentanyl — more than twice as many in 2021. Of the fentanyl-laced street pills analyzed by the DEA in 2022, 60% contained a potentially lethal dose of fentanyl. Fentanyl is increasingly found in street drugs that have been stamped with illegally purchased pill presses to look like other common pharmaceutical-grade drugs, such as oxycodone.
Naloxone can help prevent fentanyl-related deaths when it is given within a short period of time after an overdose. The nasal spray form of naloxone does not require a prescription and can be obtained from pharmacies. Naloxone acts quickly to reverse the effects of an opioid overdose, but opioids last much longer than naloxone. Additional doses of naloxone are therefore sometimes necessary. People who receive naloxone still require an emergency medical evaluation, as overdose symptoms can return. If someone who has overdosed does not have a pulse, start CPR.
Now that shipments from China have come under suspicion, the sellers told the investigators that they preferred to ship through Europe. Even as the US worked with China to crack down on one fentanyl compound, the sellers simply tweaked their formula and offered to sell a new version in another email included in the report. The staff started, quite literally, by Googling “fentanyl for sale,” they said. Posing as first-time buyers, they made contact with six responsive sellers. These sounded like sophisticated operations, offering discounts on bulk purchases and even trying to upsell the investigators to carfentanil, an even more powerful opioid.

Overdose rates have skyrocketed for nonmedical use, whether in those addicted or from accidental deaths. If you or someone you know is showing these symptoms, it is important to seek professional help immediately. Users and family members should have immediate access to naloxone (Narcan), an opioid agonist medication that rapidly reverses opioid overdose. Adverse effects occur based on dose, timing, and monitoring.
To prevent accidental fentanyl overdoses, you can use fentanyl test strips to ensure other drugs don’t contain the opioid. You can get them free through some outreach programs, such as needle exchanges or overdose prevention programs. Fentanyl can be illegally mixed into other substances, including heroin, cocaine, ecstasy, and methamphetamine (NIDA, 2021).
However, an emergency medicine called naloxone can reverse an opioid overdose related to fentanyl. Initial reports of fentanyl abuse were linked to prescription products, but in recent years, illicit fentanyl has become the most commonly abused form. In fact, most fentanyl-related deaths are from fentanyl made in illegal laboratories. Fentanyl is heavily trafficked into the US from other countries and sold as pills or powders, and it has largely replaced heroin in the drug supply. In some cases, these illicit formulations of fentanyl are made to look like other prescription opioid tablets.
He died in early 2017 from “acute fentanyl intoxication,” just about 30 days after receiving the last of 15 packages through the Postal Service. Also, an IV neuromuscular blocker may be employed in cases of severe muscular rigidity to assist the controlled respiration treatments. Fentanyl is hepatically metabolized via the CYP450 enzyme system, specifically CYP3A4. Medical experts said fentanyl isn’t volatile, meaning it doesn’t easily become a vapor, which means you’re not going to become sick from breathing near it.
People taking a daily prescribed dose will become dependent on the drug and will have withdrawal symptoms if they stop it. This is not an addiction but instead a physiological response. While the dangers of addiction to fentanyl cannot be understated, one should not focus on addiction but on the dangers of the drug itself, with or without addiction.

Many people worry that calling emergency services for someone taking an illegal drug will get them in trouble, but this is not true. Many states have laws that protect not only the person who calls for help, but also the person overdosing from legal trouble. While it’s safe for your doctor to give you fentanyl in a medical setting, some people abuse it, which can lead to an overdose. Fentanyl comes as a lozenge on a handle, a sublingual (underneath the tongue) tablet, and a buccal (between the gum and cheek) tablet to dissolve in the mouth.